Therapeutic Effect of Agaricus brasiliensis on Phenylhydrazine-Induced Neonatal Jaundice in Rats
نویسندگان
چکیده
The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.
منابع مشابه
Role of bilirubin as antioxidant in neonatal jaundice and effect of ethanolic extract of sweet lime peel on experimentally induced jaundice in rat.
Bilirubin above a threshold level is toxic to human system and is excreted in urinary and through gastrointestinal tract. The role of bilirubin as antioxidant is debatable. This paper aims at elucidating the role of bilirubin as an antioxidant in neonatal jaundice patients. It is observed that bilirubin up to 6 mg/dl in blood acts as an antioxidant and above 12.5 mg/dl is strongly prooxidant. P...
متن کاملProtective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats
Objective. The present investigation examined the neuroprotective effect of Agaricus brasiliensis (AbS) against STZ-induced diabetic neuropathic pain in laboratory rats. STZ-induced diabetic rats were administered orally with AbS. Body weight, serum glucose, and behavioral parameters were measured before and at the end of the experiment to see the effect of AbS on these parameters. After 6 week...
متن کاملAmelioration of Lipid Peroxidation and Antioxidant Enzymes Status in the Serum and Erythrocytes of Phenylhydrazine-Induced Anemic Male Rats: The Protective Role of Artichoke Extract (Cynara scolymus L.)
BACKGROUND: Hemolytic anemia is a disorder characterized by the premature erythrocytes destruction. Phenylhydrazine (PHZ) induces oxidative stress and reactive oxygen species (ROS) formation, which causes hemolytic anemia. Cynara scolymus due to its antioxidant compounds, has been used for various therapeutic purposes in traditional medicine. OBJECTIVES: The present study was designed to evalua...
متن کاملProtective Effect of Cynara scolymus L. on Blood Biochemical Parameters and Liver Histopathological Changes in Phenylhydrazine-induced Hemolytic Anemia in Rats
Background: Artichoke (Cynara scolymus) possesses bioactive components with antioxidant effects. This plant has been widely used in traditional medicine. Objectives: The current study aimed to examine the protective activity of Hydroethanolic Extract of Cynara scolymus (HECS) against experimentally-induced hemolytic anemia in rats. Methods: Hemolytic anemia was induced by intraperitoneal inj...
متن کاملEvaluation of therapeutic strategies of neonatal jaundice by medicinal herbalists of Mazandaran province: a descriptive cross sectional study
Background: Neonatal jaundice is as a disease caused by the abnormality of bilirubin metabolism that tendency of people to traditional medicine is very high for the treatment. Objective: The aim of this study was to determine the therapeutic strategies, especially herbal treatments, in the neonatal jaundice, for mother and infant, based on verbally traditional medicine recommended by medicinal ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2015 شماره
صفحات -
تاریخ انتشار 2015